A neuropeptide with diverse biological activities
货号:ajcx23302
CAS:N/A
分子式:C20H16ClD8N3S.2HCl
分子量：454.9
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prochlorperazine-d₈is intended for use as an internal standard for the quantification of prochlorperazine by GC- or LC-MS. Prochlorperazine is a dopamine D₂receptor antagonist with K_ivalues of 4.7 and 2.9 nM for rat recombinant D₂receptors in CHO cells and rat striatal membranes, respectively.^1,2It also binds to rat recombinant D₃receptors expressed in CHO cells (K_i= 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT₃in N1E-115 mouse neuroblastoma cell membranes (K_i= 1,200 nM).^1,3Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M₁muscarinic receptor.⁴It also inhibits emesis induced by apomorphine in dogs (ED₅₀= 0.34 mg/kg).⁵Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.

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