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N-Oleoyl Glutamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Oleoyl Glutamine图片
规格:98%
分子量:410.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An endogenous N-acyl amine
货号:ajcx23128
CAS:247150-73-8
分子式:C23H42N2O4
分子量:410.6
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-Oleoyl glutamine is an endogenous N-acyl amine.1,2It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 µM) induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64%.3It inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with transient receptor potential vanilloid 1 (TRPV1) and red fluorescent protein (RFP).2N-Oleoyl glutamine (100 mg/kg) reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice.


1.Long, J.Z., Svensson, K.J., Bateman, L.A., et al.The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondriaCell166(2)1-12(2016) 2.Long, J.Z., Roche, A.M., Berdan, C.A., et al.Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociceptionProc. Natl. Acad. Sci. U.S.A.115(29)E6937-E6945(2018) 3.Lin, H., Long, J.Z., Roche, A.M., et al.Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogues that stimulate mitochondrial respirationJ. Med. Chem.61(7)3224-3230(2018)