A neuropeptide with diverse biological activities
货号:ajcx22962
CAS:N/A
分子式:C22H33D5O5
分子量：387.6
溶解度:DMF: 100 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1.6 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Misoprostol-d₅is intended for use as an internal standard for the quantification of misoprostol by GC- or LC-MS. Misoprostol is an analog of prostaglandin E₁and an agonist of the PGE₂receptor subtypes EP₂and EP₃.^1,2,3It binds to EP₁, EP₂, EP_3-III, and EP₄receptors (K_is = 35.675, 10.249, 0.319, 5.499 μM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (K_is = >100 μM for all).¹Misoprostol inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC₅₀s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP₂and EP₃receptors, respectively.^3,4It inhibits FMLP-induced superoxide anion generation in human neutrophils (EC₅₀= 0.35 μM).²Misoprostol inhibits ethanol-induced gastric lesion formation in rats (ED₅₀= 0.31 μg/kg).⁵Formulations containing misoprostol have been used in the prevention of NSAID-induced gastric ulcers.

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