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Meclizine-d8(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Meclizine-d8(hydrochloride)图片
规格:98%
分子量:471.9
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of meclizine
货号:ajcx22896
CAS:1432062-16-2
分子式:C25H19ClD8N2.2HCl
分子量:471.9
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Meclizine-d8is intended for use as an internal standard for the quantification of meclizine by GC- or LC-MS. Meclizine is a histamine H1receptor antagonist (Ki= 250 nM).1Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.2Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.


1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978) 2.Pasquale, C.P., e Silva, P.M., Lima, M.C., et al.Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized ratsEur. J. Pharmacol.223(1)9-14(1992)