A neuropeptide with diverse biological activities
货号:ajcx22602
CAS:N/A
分子式:C21H26D6O2
分子量：322.5
溶解度:DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2):< 100 μg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Heneicosapentaenoic acid-d₆(HPA-d₆) contains six deuterium atoms at the 3, 3', 4, 4', 5, and 5' positions. It is intended for use as an internal standard for the quantification of HPA by GC-or LC-mass spectrometry. HPA is a ω-3 fatty acid present in trace amounts in the green algaB. pennataLamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the δ⁶position.¹HPA can be used to study the significance of the position of the double bonds in n-3 fatty acids. It incorporates into phospholipids and into triacylglycerolin vivowith the same efficiency as EPA and docosahexaenoic acid (DHA) and exhibits strong inhibition of arachidonic acid synthesis from linoleic acid.¹HPA is a poor substrate for PGH synthase and for 5-LO but retains the ability to rapidly inactivate PGH synthase.¹

1.Larsen, L.N., Hovik, K., Bremer, J., et al.Heneicosapentaenoate (21:5n-3): Its incorporation into lipids and its effects on arachidonic acid and eicosanoid synthesisLipids32707-714(1997)