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Dipyridamole-d16
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dipyridamole-d16图片
包装:5mg
规格:98%
市场价:11839元
分子量:520.7

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22308
CAS:N/A
分子式:C24H24D16N8O4
分子量:520.7
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dipyridamole-d16is intended for use as an internal standard for the quantification of dipyridamole by GC- or LC-MS. Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50= 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosineviared blood cells.1,2It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and thrombin generation.1Dipyridamole has also been shown to inhibit PDE11A with an IC50value of 370 nM and equilibrative nucleoside transporter 1 (ENT1) with a Kivalue of 8.18 nM.3,4Formulations containing dipyridamole in combination with aspirin have been used to prevent stroke and other cardiovascular events.


1.Rondina, M.T., and Weyrich, A.S.Targeting phosphodiesterases in anti-platelet therapyAntiplatelet Agents. Handbook of Experimental Pharmacology210225-238(2012) 2.Watanabe, N., Adachi, H., Takase, Y., et al.4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5J. Med. Chem.43(13)2523-2529(2000) 3.Fawcett, L., Baxendale, R., Stacey, P., et al.Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11AProc. Natl. Acad. Sci. USA97(7)3702-3707(2000) 4.Lin, W., and Buolamwini, J.K.Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitorsJ. Med. Chem.50(16)3906-3920(2007)