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Dihomo-&gamma-Linolenic Acid-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dihomo-&gamma-Linolenic Acid-d6图片
规格:98%
分子量:312.5
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of DGLA
货号:ajcx22288
CAS:81540-86-5
分子式:C20H28D6O2
分子量:312.5
溶解度:0.15 M Tris-HCl pH 8.5: 1 mg/ml,DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 100 μg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dihomo-γ-Linolenic Acid-d6(DGLA-d6) contains six deuterium atoms at the 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of DGLA by GC-or LC-mass spectrometry. Dihomo-γ-Linolenic Acid (DGLA, 20:3), an elongation product of γ-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, (PGs), including PGE1.1,2In mice, DGLA supplementation in the diet can reduce atopic dermatitis and atherosclerosis.3,4


1.Bell, J.G., Tocher, D.R., and Sargent, J.R.Effect of supplementation with 20:3(n-3), 20:4(n-6) and 20:5(n-3) on the production of prostaglandins E and F of the 1-, 2- and 3-series in turbot (Scophthalmus maximus) brain astroglial cells in primary cultureBiochimica et Biophysica Acta1211335-342(1994) 2.Levin, G., Duffin, K.L., Obukowicz, M.G., et al.Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2Biochemistry Journal365489-496(2002) 3.Kawashima, H., Tateishi, N., Shiraishi, A., et al.Oral administration of dihomo-γ-linolenic acid prevents development of atopic dermatitis in NC/Nga miceLipids43(1)37-43(2007) 4.Takai, S., Jin, D., Kawashima, H., et al.Anti-atherosclerotic effects of dihomo-γ-linolenic acid in ApoE-deficient miceJ.Atheroscer.Thromb.16(4)480-489(2009)