A neuropeptide with diverse biological activities
货号:ajcx21848
CAS:N/A
分子式:C15H7BrD4NO3.Na
分子量：360.2
溶解度:DMSO: 100 mM,Ethanol: 5 mM,Water: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bromfenac-d₄is intended for use as an internal standard for the quantification of bromfenac by GC- or LC-MS. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC₅₀= 6.6 nM) that is selective over COX-1 (IC₅₀= 210 nM).¹It inhibits prostaglandin E₂production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks.²Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.

1.Waterbury, L.D., Silliman, D., and Jolas, T.Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodiumCurr. Med. Res. Opin.22(6)1133-1140(2006) 2.Brookshire, H.L., English, R.V., Nadelstein, B., et al.Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removalVet. Ophthalmol.18(3)175-185(2015)