A tetrapeptide -opioid receptor agonist
货号:ajcx21812
CAS:2393866-13-0
分子式:C28H38N4O6
分子量：526.6
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bilaid C is a tetrapeptide µ-opioid receptor agonist (K_i= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.¹It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human µ-opioid receptor when used at a concentration of 10 µM. Bilaid C induces inward rectifying potassium channel (K_ir) currents in rat locus coeruleus slices that endogenously express high levels of the µ-opioid receptor (EC₅₀= 4.2 µM).

1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019)