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Azithromycin-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azithromycin-d3图片
包装:1mg
规格:98%
市场价:3333元
分子量:752

产品介绍
阿奇霉素-d3 (CP 62993-d3) 是氘标记的阿奇霉素。
货号:ajcx21766
CAS:163921-65-1
分子式:C38H69D3N2O12
分子量:752
溶解度:DMSO: 100 mg/ml,Ethanol: 100 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Azithromycin-d3is intended for use as an internal standard for the quantification of azithromycin by GC- or LC-MS. Azithromycin is a macrolide antibiotic.1It is active againstS. pneumoniae,S. aureus,N. gonorrhoeae,M. pneumoniae,H. pylori,C. trachomatis, andH. influenzae in vitro(MIC90s =<0.01-2 mg/L). Azithromycin increases survival in mouse models of intraperitonealS. pyogenes,S. pneumoniae,E. faecalis, orH. influenzaeinfection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).2It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.3Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.


1.Kanatani, M.S., and Guglielmo, B.J.The new macrolides. Azithromycin and clarithromycinWestern J. Med.160(1)31-37(1994) 2.Girard, D., Finegan, S.M., Dunne, M.W., et al.Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection modelsJ. Antimicrob. Chemother.56(2)365-371(2005) 3.Patel, A., Joseph, J., Periasamy, H., et al.Azithromycin in combination with ceftriaxone reduces systemic inflammation and provides survival benefit in a murine model of polymicrobial sepsisAntimicrob. Agents Chemother.62(9)e00752-00718(2018)