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15-keto Prostaglandin E2-d9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
15-keto Prostaglandin E2-d9图片
规格:98%
分子量:359.5
包装与价格:
包装价格(元)
50ug电议
100ug电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21136
CAS:N/A
分子式:C20H21D9O5
分子量:359.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

15-keto Prostaglandin E2-d9(15-keto PGE2-d9) is intended for use as an internal standard for the quantification of 15-keto PGE2by GC- or LC-MS. 15-keto PGE2is a metabolite of PGE2formed by 15-hydroxy PGDH.1,2In vivo, 15-keto PGE2is essentially inactive. It has an attenuated affinity for the EP4and EP2receptors compared to PGE2(Ki= 2,600-15,000 nM for the inhibition of PGE2binding compared to a Kd= 1 nM for PGE2).3


1.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971) 2.Mak, O.T., Liu, Y., and Tai, H.H.Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidneyBiochim. Biophys. Acta1035(2)190-196(1990) 3.Nishigaki, N., Negishi, M., and Ichikawa, A.Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonistMol. Pharmacol.50(4)1031-1037(1996)