A bicyclic γ-lactone
货号:ajcx20808
CAS:43119-28-4
分子式:C7H8O2
分子量：124.1
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml,Ethanol: 15 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(-)-G-lactone is a bicyclic γ-lactone prostaglandin chiral synthon and a building block.^1,2It is a prostaglandin chiral synthon formed from an asymmetric Baeyer-Villiger oxidation reaction.¹(-)-G-lactone has also been used as a building block in the synthesis of HIV-1 protease inhibitors.²

1.Alphand, V., Archelas, A., and Furstoss, R.Microbial Transformations 16. One-step synthesis of a pivotal prostaglandin chiral synthon via a highly enantioselective microbiological Baeyer-Villiger type reactionTetrahedron Lett.30(28)3663-3664(1989) 2.Ghosh, A.K., Chapsal, B.D., Baldridge, A., et al.Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P2 ligands: Structure-activity studies and biological evaluationJ. Med. Chem.54(2)622-634(2011)