Norwogonin 是从黄芩中分离出来的，对肠道病毒 71 (EV71) 具有抗病毒活性，IC50 为 31.83 μg/mlIC50 ！！！目标:IC50:31.83 μg/ml (EV71) 体外:Norwogonin（0.4、2、10 和 50 μg/mL；48 小时）抑制 EV71 在 Vero 细胞中的复制并防止 EV71 感染引起的细胞毒性。
货号:ajcx20348
CAS:4443-09-8
分子式:C15H10O5
分子量：270.2
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.1 mg/ml,Ethanol: 0.1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Norwogonin is a polyhydroxy flavone that has been found in S. baicalensis and has diverse biological activities, including antioxidant, antiviral, and anticancer properties.1,2,3 It scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals with IC50 values of 1.24 and 35.61 μg/ml, respectively, in cell-free assays.1 Norwogonin inhibits cytopathic effects induced by enterovirus 71 (EV71) in infected Vero cells (IC50 = 31.83 μg/ml).2 It reduces the viability of MDA-MB-231, BT-549, HCC70, and HCC1806 triple-negative breast cancer (TNBC) cells (IC50s = 32.24, 56.2, 39.05, and 37.3 μM, respectively) but not the non-tumorigenic cell lines MCF-10A and AG11132 (IC50s = >100 μM for both).3 Norwogonin induces cell cycle arrest at the G1 and G2/M phases and increases apoptosis in MDA-MB-231 cells in a concentration-dependent manner.

|1. Sarian, M.N., Ahmed, Q.U., Mat So'ad, S.Z., et al. Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study. Biomed. Res. Int. 2017:8386065, (2017).|2. Choi, H.J., Song, H.-H., Lee, J.-S., et al. Inhibitory effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71. Biomol. Ther. (Seoul) 24(5), 552-558 (2016).|3. Abd El-Hafeez, A.A., Khalifa, H.O., Mahdy, E.A.M., et al. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-κB, and STAT3. Pharmacol. Rep. 71(2), 289-298 (2019).