OUL35 (NSC39047) 是一种有效的选择性 ARTD10 (PARP-10) 抑制剂，IC50 为 329 nM。
货号:ajcx20070
CAS:6336-34-1
分子式:C14H12N2O3
分子量：256.3
溶解度:DMF: 5 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).1 It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea , increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.

|1. Venkannagari, H., Verheugd, P., Koivunen, J., et al. Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem. Bio. 23(10), 1251-1260 (2016).