Vulpinic acid 是一种地衣代谢物，可减少人脐静脉内皮细胞 (HUVEC) 中 H2O2 诱导的 ROS 产生、氧化应激和氧化应激相关损伤。
货号:ajcx19672
CAS:521-52-8
分子式:C19H14O5
分子量：322.3
溶解度:DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Vulpinic acid is a lichen metabolite that has been found in L. vulpina and has diverse biological activities.1,2,3,4 It is active against C. perfringens, B. vulgatus, B. fragilis, B. loescheii, P. acnes, E. faecium, and methicillin-susceptible and -resistant S. aureus (MICs = 4-16 μg/ml).1 Vulpinic acid (25-800 μM) prevents UVB-induced apoptosis, cytotoxicity, and cytoskeletal modifications in HaCaT human keratinocytes.2 It also increases scratch wound healing of HaCaT cells.3 Vulpinic acid (15 μM) reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and cytotoxicity in human umbilical vein endothelial cells (HUVECs).4

参考文献
1. Lauterwein, M., Oethinger, M., Belsner, K., et al. In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (—)-usnic acid against aerobic and anaerobic microorganisms. Antimicrob. Agents Chemother. 39(11), 2541-2543 (1995).
2. Varol, M., TÜrk, A., Candan, M., et al. Photoprotective activity of vulpinic and gyrophoric acids toward ultraviolet B-induced damage in human keratinocytes. Phytother. Res. 30(1), 9-15 (2016).
3. Burlando, B., Ranzato, E., Volante, A., et al. Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds. Planta. Med. 75(6), 607-613 (2009).
4. Sahin, E., Psav, S.D., Avan, I., et al. Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. Hum. Exp. Toxicol. 38(6), 675-684 (2019).