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Estrone 3-methyl ether
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estrone 3-methyl ether图片
规格:98%
分子量:284.4
包装与价格:
包装价格(元)
500mg电议
1g电议
5g电议
10g电议

产品介绍
C19H24O2
货号:ajcx19422
CAS:1624-62-0
分子式:C19H24O2
分子量:284.4
溶解度:Chloroform: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Estrone 3-methyl ether is a synthetic estrogen and derivative of estrone .1 It stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro when used at concentrations ranging from 0.16 to 20 μM but lacks estrogen receptor (ER) binding activity (IC50s = >100 μM for ERα and ERβ). Estrone 3-methyl ether has been used in the synthesis of various estrogen receptor modulators.2

参考文献
1. Alsayari, A., Kopel, L., Ahmed, M.S., et al. Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents. Steroids 118, 32-40 (2017).
2. Kuznetsov, Y.V., Levina, I.S., Scherbakov, A.M., et al. New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5(10)-trienes: Synthesis, molecular modeling, and biological evaluation. Eur. J. Med. Chem. 143, 670-682 (2018).