Manumycin A is a Farnesyltransferase inhibitor which suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells, inhibiting IKKβ activity through covalent cross-linking of IKKβ monomers via C179. References: Tuladhar A, Hondal RJ, Colon R, Hernandez EL, Rein KS. Effectors of thioredoxin reductase: Brevetoxins and manumycin-A. Comp Biochem Physiol C Toxicol Pharmacol. 2019 Mar;217:76-86. doi: 10.1016/j.cbpc.2018.11.015. Epub 2018 Nov 23. PubMed PMID: 30476593.

纯度：≥98%

CAS：52665-74-4