SMAP-2 (DT-1154) 是一种可口服生物利用的磷酸酶 2A (PP2A) 激活剂，绑定到支架亚基 PP2A Aα 上使 PP2A 构象变化。SMAP-2 (DT-1154) 能抑制 KRAS 突变肺癌的增长。
货号:ajcx16636
CAS:1809068-70-9
分子式:C27H27F3N2O4S
分子量：532.57
溶解度:DMSO: 300 mg/mL (563.31 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].

[1]. Sangodkar J, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 1;127(6):2081-2090.