LSN2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). LSN2814617 reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in rat models. References: Loomis S, McCarthy A, Baxter C, Kellett DO, Edgar DM, Tricklebank M, Gilmour G. Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617. Psychopharmacology (Berl). 2015 Nov;232(21-22):3977-89. doi: 10.1007/s00213-015-3936-8. PubMed PMID: 25902875; PubMed Central PMCID: PMC4600478.

纯度：≥98%

CAS：1313498-08-6