Obtusin 是来自决明子种子，是一种高度选择性和竞争性的人单胺氧化酶-A (hMAO-A) 抑制剂，IC50 为 11.12 μM，Ki 为 6.15。Obtusin 在神经退行性疾病，尤其是焦虑和抑郁中起预防作用。
货号:ajcx15818
CAS:70588-05-5
分子式:C18H16O7
分子量：344.32
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1].

[1]. Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152.