DNA2 inhibitor C5 是一种有效的，竞争性，特异性的 DNA2 核酸酶活性抑制剂，IC50 为 20 μM。DNA2 inhibitor C5 抑制 DNA2 的核酸酶，DNA 依赖性 ATPase，解旋酶和 DNA 结合活性。DNA2 inhibitor C5 可用于开发引起复制压力的癌症化学治疗剂的敏化剂。
货号:ajcx14462
CAS:35973-25-2
分子式:C10H6N2O5
分子量：234.17
溶解度:DMSO: 31.25 mg/mL (133.45 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].

[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.