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CTX-0294885 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CTX-0294885 hydrochloride图片
规格:98%
分子量:474.39
包装与价格:
包装价格(元)
5mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
CTX-0294885 hydrochloride是琼脂糖支持的激酶捕获试剂。
货号:ajcx13814
CAS:N/A
分子式:C22H25Cl2N7O
分子量:474.39
溶解度:H2O: ≥ 370 mg/mL (779.95 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CTX-0294885 hydrochloride is a sepharose-supported kinase capture reagent.

CTX-0294885 is a novel bisanilino pyrimidine exhibiting inhibitory activity against a broad range of kinases. CTx-0294885 represents a powerful new reagent for analysis of kinome signaling networks that may facilitate development of targeted therapeutic strategies. Large-scale CTx-0294885-based affinity purification followed by LC-MS/MS leads to the identification of 235 protein kinases from MDA-MB-231 cells, including all members of the AKT family that has not been previously detected by other broad-spectrum kinase inhibitors. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase-enrichment increases the number of kinase identifications to 261. Combining CTx-0294885 with three other broad-specificity inhibitors for kinase enabled the identification of 799 highconfidence phosphosites on 183 kinases, 10% of which are localized to the activation loop, and included previously unreported phosphosites on BMP2K, MELK, HIPK2, and PRKDC[1].


[1]. Zhang L, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16.