DUPA是一种谷氨酸脲，在药物耦联中作为靶向部分，可选择靶向性地将细胞毒性药物递送到前列腺癌细胞。
货号:ajcx13596
CAS:302941-52-2
分子式:C11H16N2O9
分子量：320.25
溶解度:H2O : ≥ 150 mg/mL (468.38 mM), DMSO : ≥ 300 mg/mL (936.77 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells[1][2].

DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer[1]. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures[2].

The DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice[2].

[1]. Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80. [2]. Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.