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GC 14
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GC 14图片
规格:98%
分子量:449.5
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
GC14是甲状腺激素(thyroidhormone)的拮抗剂。
货号:ajcx13100
CAS:447415-34-1
分子式:C26H27NO6
分子量:449.5
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

GC 14 is a thyroid hormone antagonist.

GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[2].


[1]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [2]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20.