包装: | 10mg |
规格: | 98% |
市场价: | 3351元 |
分子量: | 310.78 |
Background:
MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7?μM for Pam3CSK4-induced hTLR2/1 and 5.7?μM for Pam2CSK4-induced hTLR2/6 responses[1].
MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100?μM) shows no cytotoxic effects up to 100?μM in peripheral blood mononuclear cells (PBMCs)[1].
参考文献:
[1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160.