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Homo-PROTAC pVHL30 degrader 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Homo-PROTAC pVHL30 degrader 1图片
规格:98%
分子量:1179.45
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Homo-PROTAC pVHL30 degrader 1 是基于 PROTAC 的有效 pVHL30 降解剂。
货号:ajcx39282
CAS:2244684-49-7
分子式:C58H82N8O14S2
分子量:1179.45
溶解度:DMSO : ≥ 150 mg/mL (127.18 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.