Umbellulone 是 Umbellularia californica 叶中的一种活性成分。在肽能、伤害感受神经元亚群中，Umbellulone 刺激 TRPA1通道，并通过这一机制激活三叉神经血管系统。
货号:ajcx39136
CAS:546-78-1
分子式:C10H14O
分子量：150.22
溶解度:DMSO : 250 mg/mL (1664.23 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1].

Umbellulone, from µM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells[1].

Umbellulone (50-250 nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1+/+ mice[1].Umbellulone (150 µg/kg; intravenous or intranasal) do not affect systemic blood pressure[1].Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner[1].

[1]. Nassini R, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain. 2012 Feb;135(Pt 2):376-90.