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Ensitrelvir fumarate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ensitrelvir fumarate图片
规格:98%
分子量:647.95
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Ensitrelvir (S-217622) fumarate 是第一个具有口服活性的,非共价的、非肽 SARS-CoV-2 3CL 蛋白酶抑制剂 (IC50=13 nM)。
货号:ajcx37480
CAS:2757470-18-9
分子式:C26H21ClF3N9O6
分子量:647.95
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM)[1][2].

In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir fumarate shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants. EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively[1].

Ensitrelvir fumarate dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice[2].

[1]. McKimm-Breschkin JL, et al. COVID-19, Influenza and RSV: Surveillance-informed prevention and treatment - Meeting report from an isirv-WHO virtual conference. Antiviral Res. 2022;197:105227. [2]. Yuto Unoh, et al. Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19. bioRxiv 2022.01.26.477782.