PROTAC ER Degrader-4 是一种基于 von Hippel-Lindau 的 PROATC 雌激素受体 (ER) 降解剂，与 ER 结合，IC50 为 0.8 nM。PROTAC ER Degrader-4 在 MCF-7 细胞中诱导 ER 降解，IC50 为 0.3 nM。
货号:ajcx37444
CAS:2361114-15-8
分子式:C53H67F3N6O8S
分子量：1005.19
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].

PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].

[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.