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Rivastigmine carbamate impurity
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rivastigmine carbamate impurity图片
规格:98%
分子量:224.21
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) 是 Rivastigmine 的杂质。Rivastigmine 是一种具有口服活性的,有效的胆碱酯酶 (ChE) 抑制剂,可抑制丁酰胆碱酯酶 (BChE) 和乙酰胆碱酯酶 (AChE),IC50 分别为 0.037 μM 和 4.15 μM。
货号:ajcx37318
CAS:1346242-31-6
分子式:C10H12N2O4
分子量:224.21
溶解度:DMSO : 100 mg/mL (446.01 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively[1][2].

[1]. Ziwei Chen, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer’s disease. Eur J Med Chem. 2017 Jan 5;125:784-792.
[2]. Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45(17):3684-91.