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PD-L1-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD-L1-IN-1图片
规格:98%
分子量:377.44
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
PD-L1-IN-1 是一种有效的 PD-L1 抑制剂,IC50 为 115 nM。PD-L1-IN-1与PD-L1蛋白强结合,并在表达 PD-L1 的癌细胞(PC9 和 HCC827 细胞)和外周血单核细胞的共同培养中激发 PD-L1 蛋白,增强后者的抗肿瘤免疫活性。PD-L1-IN-1 显著增加了干扰素 γ 的释放和癌细胞的凋亡诱导,对健康细胞的细胞毒性较低。
货号:ajcx36744
CAS:N/A
分子式:C21H23N5O2
分子量:377.44
溶解度:DMSO : 125 mg/mL (331.18 mM; ultrasonic and warming and heat to 60°C)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells[1].

[1]. Russomanno P, et al. Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors. J Med Chem. 2021;64(21):16020-16045.