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SGC-SMARCA-BRDVIII
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SGC-SMARCA-BRDVIII图片
规格:98%
分子量:371.43
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
SGC-SMARCA-BRDVIII 是一种有效和选择性的 SMARCA2/4 和 PB1(5) 抑制剂,Kd 值分别为 35 nM,36 nM 和 13 nM。SGC-SMARCA-BRDVIII 还抑制 PB1(2) 和 PB1(3),Kd 值分别为 3.7 和 2.0 μM。SGC-SMARCA-BRDVIII 可以阻断 3T3-L1 鼠成纤维细胞的脂肪生成。
货号:ajcx36554
CAS:1997319-84-2
分子式:C19H25N5O3
分子量:371.43
溶解度:DMSO : 25 mg/mL (67.31 mM; ultrasonic and warming and heat to 60°C)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].

SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts[1].

[1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699.
[2]. MÉlin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338.