您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > MRT-83 hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MRT-83 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MRT-83 hydrochloride图片
规格:98%
分子量:575.05
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
MRT-83 (hydrochloride) 是 Smoothened (Smo) 受体的有效拮抗剂。MRT-83 (hydrochloride) 抑制 Hedgehog (Hh) 信号通路和 BODIPY-cyclopamine 与人 Smo 的结合。MRT-83 (hydrochloride) 具有研究癌症疾病的潜力。
货号:ajcx36506
CAS:1359944-60-7
分子式:C31H31ClN4O5
分子量:575.05
溶解度:DMSO : 250 mg/mL (434.74 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].

MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1].

[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.