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BPAM344
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BPAM344图片
规格:98%
分子量:242.27
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
BPAM344 是红藻氨酸受体 (KAR) 亚基 GluK1b、GluK2a 和 GluK3a 的正变构调节剂 (PAM)。
货号:ajcx34582
CAS:1204572-55-3
分子式:C10H11FN2O2S
分子量:242.27
溶解度:DMSO : 250 mg/mL (1031.91 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].

BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1].

[1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585.