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AR453588
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AR453588图片
规格:98%
分子量:519.64
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
AR453588 是一种有效的口服生物利用的抗糖尿病葡萄糖激酶 (glucokinase) 激活剂,EC50为 42 nM。AR453588 具有降血糖作用。
货号:ajcx34526
CAS:1065609-00-8
分子式:C25H25N7O2S2
分子量:519.64
溶解度:DMSO : 100 mg/mL (192.44 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity[1].

AR453588 (3-30 mg/kg; p.o) lowers post-prandial glucose in normal C57BL/6J mice[1].AR453588 (3-30 mg/kg; p.o.; once-daily for 14 days) shows anti-hyperglycemic activity in a dose-ranging 14 day ob/ob mouse[1].AR453588 (10 mg/kg; p.o.) treatment shows that the Tmax, AUCinf, Vss, Cmax and F are 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively[1].AR453588 (1 mg/kg; i.v.) treatment shows that the CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg /mL, 0.746 L/kg and 1.28 hours, respectively[1].

[1]. Hinklin RJ, et al. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg Med Chem. 2020 Jan 1;28(1):115232.