NSAH 是可逆的、竞争性的非核苷类的核苷酸还原酶 (RR)的抑制剂，其 cell-free 和 cell-bases 的 IC50 值分别为 32 μM 和 ~250 nM。
货号:ajcx34202
CAS:1099592-35-4
分子式:C18H14N2O3
分子量：306.32
溶解度:DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells[1].NSAH (0-10 μM, 2, 6, 24, or 72 h) exhibits potent anti-tumor activity in 3 cancer cell lines[1].NSAH blocks S-phase progression well to the extent and timing of the decreases in dATP and dGTP[1].

[1]. Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246.