AS1708727 是口服有效的 Foxo1 抑制剂，其对 G6Pase 和 PEPCK 的 EC50 值分别为 0.33 μM 和0.59 μM。
货号:ajcx33468
CAS:1253226-93-5
分子式:C24H24Cl2N2O2
分子量：443.37
溶解度:DMSO : 41.67 mg/mL (93.98 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively[1].

AS1708727 suppresses increases in blood glucose level by inhibiting gluconeogenic gene expression[1].

AS1708727 (30 to 300 mg/kg, orally) reduces both blood glucose and triglyceride levels, exhibiting anti-diabetic effects[1].

[1]. Hirotsugu Tanaka, et al. Effects of the Novel Foxo1 Inhibitor AS1708727 on Plasma Glucose and Triglyceride Levels in Diabetic Db/Db Mice. Eur J Pharmacol. 2010 Oct 25;645(1-3):185-91.