Slingshot inhibitor D3 是一种有效、选择性、可逆和竞争性的 Slingshot 抑制剂。Slingshot 1 的IC50 为 3 μM, Slingshot 2 的 Ki 为 3.9 μM。Slingshot inhibitor D3 对Slingshot 1 和 Slingshot 2 具有相似的抑制活性。
货号:ajcx33086
CAS:1715076-35-9
分子式:C25H19NO4S2
分子量：461.55
溶解度:DMSO : 25 mg/mL (54.17 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2[1].

Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes[1].Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation[1].Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot[1].

[1]. Li KS, et al. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem. 2015;10(12):1980-1987.