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Cl-NQTrp
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cl-NQTrp图片
规格:98%
分子量:394.81
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Cl-NQTrp 显著破坏 tau 衍生的 PHF6 (VQIVYK) 肽和全长 tau 蛋白的预制纤维聚集物。
货号:ajcx32644
CAS:185351-23-9
分子式:C21H15ClN2O4
分子量:394.81
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2].

Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils[1].Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers[1].

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau[2].Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29[2].

参考文献:
[1]. V Guru KrishnaKumar, et al. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Sci Rep. 2018 Jan 8;8(1):71.
[2]. Moran Frenkel-Pinter, et al. Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neurodegener Dis. 2017;17(2-3):73-82.