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MCU-i4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCU-i4图片
规格:98%
分子量:377.48
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
MCU-i4阻断IP3依赖的线粒体Ca2+的摄取,维持靶点的"管家"角色。
货号:ajcx32458
CAS:371924-24-2
分子式:C23H27N3O2
分子量:377.48
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].

MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts.


[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.