M617TFA是一种选择性甘丙肽受体1(GAL1)激动剂，对GAL1和GAL2的Ki分别为0.23和5.71nM。M617TFA通过其中枢GAL1作用，促进2型糖尿病大鼠心肌GLUT4的表达，提高GLUT4的含量。
货号:ajcx32098
CAS:N/A
分子式:C114H162F3N29O30
分子量：2475.67
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

M617 TFA is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617 TFA, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats[1][2].

[1]. LundstrÖm, L., et al. A Galanin Receptor Subtype 1 Specific Agonist. Int J Pept Res Ther 11, 17-27 (2005). [2]. Fang P, et al. Central injection of GalR1 agonist M617 facilitates GLUT4 expression in cardiac muscle of type 2 diabetic rats. Exp Gerontol. 2015;65:85-89.