Betazole(Ametazole)是一种吡唑类组胺，是一种口服活性H2受体激动剂。Betazole诱导胃酸分泌，导致胆总管压力立即显著升高。Betazole被用作一种被称为histalog的诊断剂，用于研究胃酸分泌能力。
货号:ajcx31966
CAS:105-20-4
分子式:C5H9N3
分子量：111.15
溶解度:DMSO: 250 mg/mL (2249.21 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity[1][2][3].

Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1].

[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.