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IRBP(1-20),human TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:2308.62
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
IRBP(1-20),humanTFA包含H-2b单倍型的主要表位。IRBP(1-20),humanTFA诱导H-2b小鼠实验性自身免疫性葡萄膜视网膜炎(EAU)。
货号:ajcx31888
CAS:N/A
分子式:C103H165F3N24O30S
分子量:2308.62
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

IRBP (1-20), human TFA contains a major epitope for the H-2b haplotype. IRBP (1-20), human TFA induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2].


IRBP (1-20), human TFA induces EAU[2].For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide[2]. Animal Model: C57BL/6 (H-2b) mice, H-2b (C57BL/6, 129/J) mice[2]

[1]. Avichezer D, et al. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp Eye Res. 2000;71(2):111‐118. [2]. Avichezer D, Silver PB, Chan CC, Wiggert B, Caspi RR. Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000;41(1):127‐131.