您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > TXNIP-IN-1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TXNIP-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TXNIP-IN-1图片
包装:5mg
规格:98%
市场价:3528元
分子量:248.23

产品介绍
TXNIP-IN-1是一种硫氧还蛋白-硫氧还蛋白相互作用蛋白(TXNIP-TRX)复合物抑制剂,详细信息请参考专利文献US20200085800A1中的化合物1。TXNIP-IN-1可用于TXNIP-TRX复合物相关代谢紊乱(糖尿病)、心血管疾病或炎症疾病的研究。
货号:ajcx31628
CAS:1268955-50-5
分子式:C12H12N2O4
分子量:248.23
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease[1].

TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation[1].TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF in monocytes[1].TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression in THP1 cells[1].TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages[1].TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels in MIN6 cells[1].TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells[1].TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose[1].TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets[1].


[1]. Rama Natarajan, et al. Txnip-trx complex inhibitors and methods of using the same. US20200085800A1.