SpadinTFA是一种从血液中释放的前肽衍生的天然肽，能够阻断TREK-1(KCNK2或K2P2.1)通道的活性。SpadinTFA与TREK-1特异性结合，亲和力为10nM。SpadinTFA是一种有效的抗抑郁药。
货号:ajcx31492
CAS:N/A
分子式:C92H143F3N26O24
分子量：2126.36
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice[1].

[1]. Jean Mazella, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.