PRI-724选择性抑制CBP/β-catenin相互作用。
货号:ajcx31336
CAS:1422253-38-0
分子式:C33H35N6O7P
分子量：658.64
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].

[1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.