Thalidomide-5-OH是一种基于Thalidomide的，可募集CRBN蛋白的cereblon配体。Thalidomide-5-OH可通过linker与靶蛋白配体连接，形成PROTAC分子。
货号:ajcx29728
CAS:64567-60-8
分子式:C13H10N2O5
分子量：274.23
溶解度:DMSO: 62.5 mg/mL (227.91 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

[1]. Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.