TH1834是一种特异性的Tip60(KAT5)组蛋白乙酰转移酶抑制剂。TH1834可诱导乳腺癌细胞凋亡并增加DNA损伤。TH1834不影响相关组蛋白乙酰转移酶MOF的活性。TH1834具有抗癌活性。
货号:ajcx29724
CAS:2108830-08-4
分子式:C33H40N6O3
分子量：568.71
溶解度:Methanol: 5 mg/mL (8.79 mM); DMSO: 5 mg/mL (8.79 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1].

TH1834 (0-500 μM; 1 hour; MCF7 cells) treatment significantly reduces the viability of MCF7 cells[1].TH1834 (0-500 μM; 1 hour; MCF7 cells) treatment significantly increases cytotoxicity in MCF7 cells[1].TH1834 (500 μM; 1 hour; MCF7 cells) treatment induces caspase 3 activation in MCF7 cells[1]. TH1834 significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage in breast cancer[1]. Cell Viability Assay[1] Cell Line: MCF7 cells

[1]. Gao C, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014 Jun 20;4:5372.