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NP-G2-044
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NP-G2-044图片
规格:98%
分子量:399.37
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
NP-G2-044是一种有效的、具有口服活性的fascin蛋白抑制剂,IC50值约为2μM。NP-G2-044可阻断肿瘤转移并增强抗肿瘤免疫应答。
货号:ajcx29554
CAS:1807454-59-6
分子式:C21H16F3N3O2
分子量:399.37
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response[1][2].

NP-G2-044 inhibits the migration of MDA-MB-231 tumor cells with an IC50 ~10 μM. NP-G2-044 decreases filopodial formation resulting in decreased lamellipodial formation[1].

NP-G2-044 (100 mg/kg; i.p.; daily for 18 days) inhibits breast tumor metastasis in mouse models[1].Upon oral administration, NP-G2-044 targets and binds to fascin, thereby preventing the interaction of fascin with actin filaments, thereby preventing actin bundling and filopodia formation. By preventing actin cytoskeletal reorganization, the dynamic changes in cell shape that are necessary for tumor cell migration and invasion to occur are impaired, and tumor cell migration and metastasis are inhibited[3]. Animal Model: 6-8 week old female BALB/c mice (mouse model bearing 4T1 tumor cells)[1]

[1]. Han S, et al. Improving fascin inhibitors to block tumor cell migration and metastasis. Mol Oncol. 2016;10(7):966-980. [2]. Vincent Chung, et al. Abstract C053: NP-G2-044, a novel fascin inhibitor, blocks tumor metastasis and increases antitumor immune response. [3]. Fascin Inhibitor NP-G2-044.