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CU-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CU-3图片
规格:98%
分子量:392.47
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
CU-3是(5Z,2E)-CU-3的消旋体。(5Z,2E)-CU-3是一种有效的选择性抗DGKα同工酶抑制剂,IC50值为0.6μM,竞争性抑制DGKα对ATP的亲和力,Km值为0.48mM。(5Z,2E)-CU-3靶向DGKα催化区域,但不靶向调节区域。(5Z,2E)-CU-3具有抗肿瘤和免疫原性作用,增强癌细胞的凋亡和T细胞的活化。
货号:ajcx29244
CAS:861123-84-4
分子式:C16H12N2O4S3
分子量:392.47
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].


[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.